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Cyclic AMP

Promulgator: :60-92-4  Visitor: :
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Product infos:
Standard: 99% CAS NO.: 60-92-4
Chinese name:: 环磷腺苷(cAMP) Product Id: PI0080
Introduce:

【Product】  Cyclic AMP(cAMP)
【CAS No.】  60-92-4
【Synonyms】  Cyclic Adenosine Monophosphate;Adenosine Cyclohosphate;5’-cyclicmonophosphate;6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide;Acrasin;Adenosine 3',5'-cyclophosphate;Adenosine 3',5'-phosphate;Adenosine cyclic 3',5'-monophosphate;Adenosine cyclic 3',5'-phosphate;Adenosine cyclic monophosphate
【Molecule Formula】  C10H12N5O6P
【Molecule Weight】  329.21
【Structure Formula】  
                                    Cyclic AMP,CAS#60-92-4

【Description】  white or almost white powder,
【Specification】      
                            Assay …………… ≥99%
                            Loss on dry…………… ≤10%   
                            pH Value …………… 2~4
【Standards】  CP2005
【Uses】  
               Cyclic AMP(cAMP) is synthesised from ATP by adenylyl cyclase located on the inner side of the phospholipid bilayer. Adenylyl cyclase is activated by a range of signaling molecules through the activation of adenylyl cyclase stimulatory G (Gs)-coupled receptors and inhibited by agonists of adenylyl cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylyl cyclase responds more strongly to glucagon, and muscle adenylyl cyclase responds more strongly to adrenaline.
             Cyclic AMP(cAMP) decomposition into AMP is catalyzed by the enzyme phosphodiesterase.
             Cyclic AMP(cAMP) is a second messenger, used for intracellular signal transduction, such as transferring the effects of hormones like glucagon and adrenaline, which cannot pass through the cell membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon. It also regulates the passage of Ca2+ through ion channels.
【Packing】  1Kg aluminium foil bag

【Functions】

        Cyclic AMP(60-92-4) is an important second messenger. It forms, as shown, when the membrane enzyme adenylyl cyclase is activated (as indicated, by the alpha subunit of a G protein). 
        The cyclic AMP(60-92-4) then goes on the activate specific proteins. Some ion channels, for example, are gated by cyclic AMP(60-92-4). But an especially important protein activated by cyclic AMP(60-92-4) is protein kinase A, which goes on the phosphorylate certain cellular proteins. The scheme below shows how cyclic AMP activates protein kinase A.

 


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